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Therapeutic oligonucleotides / edited by Jens Kurreck

Medverkande: Kurreck, Jens, 1969- [edt].
Materialtyp: materialTypeLabelBokSerie: RSC biomolecular sciences.Förläggare: Cambridge : Royal Society of Chemistry, c2008Beskrivning: xvii, 343 p. : ill. (some col.) ; 24 cm.ISBN: 9780854041169 (hbk.).Ämnen: Nukleotider | NucleotidesOther classification: A61K31 | C07H21/00 | C12N15/11
Innehåll:
The role of backbone modifications in oligonucleotide-based strategies -- Genasense (G3139) : an antisense Bcl-2 oligodeoxyribonucleotide with substantial clinical activity and a complex mechanism of action -- Antisense morpholino oligomers and their peptide conjugates -- Peptide-peptide nucleic acid conjugates for modulation of gene expression -- Locked nucleic acid: properties and therapeutic aspects -- Immune stimulatory oligonucleotides -- Decoy oligodeoxynucleotides to treat inflammatory diseases -- AS1411 : development of an anticancer aptamer -- Spiegelmer NOX-E36 for renal diseases -- Strategies for the delivery of oligonucleotides in vivo -- Lipid-mediated in vivo delivery of small interfering RNAs -- Vector-mediated and viral delivery of short hairpin RNAs -- Development of an RNAi-based gene therapy against HIV-1 -- RNA based therapies for treatment of HIV infection.
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Includes bibliographical references and index.

The role of backbone modifications in oligonucleotide-based strategies -- Genasense (G3139) : an antisense Bcl-2 oligodeoxyribonucleotide with substantial clinical activity and a complex mechanism of action -- Antisense morpholino oligomers and their peptide conjugates -- Peptide-peptide nucleic acid conjugates for modulation of gene expression -- Locked nucleic acid: properties and therapeutic aspects -- Immune stimulatory oligonucleotides -- Decoy oligodeoxynucleotides to treat inflammatory diseases -- AS1411 : development of an anticancer aptamer -- Spiegelmer NOX-E36 for renal diseases -- Strategies for the delivery of oligonucleotides in vivo -- Lipid-mediated in vivo delivery of small interfering RNAs -- Vector-mediated and viral delivery of short hairpin RNAs -- Development of an RNAi-based gene therapy against HIV-1 -- RNA based therapies for treatment of HIV infection.

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